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( )-ar-Turmerone-d<sub>3</sub>

" in MedChemExpress (MCE) Product Catalog:

2661

Inhibitors & Agonists

9

Biochemical Assay Reagents

6

Peptides

1

Inhibitory Antibodies

8

Natural
Products

13

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2597

Isotope-Labeled Compounds

3

Antibodies

13

Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N6703S
    ar-Turmerone-d3

    (+)-ar-Turmerone-d<sub>3sub>

    		 Apoptosis Inflammation/Immunology Cancer
    ar-Turmerone-d3 is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-Turmerone activates apoptotic protein in human lymphoma U937 cells[3]. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders[4][5].
    <em>ar-Turmerone</em>-d<em>3</em>
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-10844S1
    Pretomanid-d5

    PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>

    		 Antibiotic Bacterial Isotope-Labeled Compounds Infection Cancer
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-B1689AS
    Methantheline-d3 bromide

    MTB 51-d<sub>3sub>; Mantheline-d<sub>3sub>; Metantyl-d<sub>3sub>; Metanyl-d<sub>3sub>; Metaxan-d<sub>3sub>; Methanide-d<sub>3sub>

    		 Isotope-Labeled Compounds Others
    Methantheline-d3 (bromide) is the deuterium labeled Methantheline bromide[1].
    Methantheline-d<em>3</em> bromide
  • HY-113323S
    3-Methoxy-4-hydroxyphenylglycol-d3

    HMPG-d<sub>3sub>; MHPG-d<sub>3sub>; MOPEG-d<sub>3sub>

    		 Endogenous Metabolite Others
    3-Methoxy-4-hydroxyphenylglycol-d3 is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.
    <em>3</em>-Methoxy-4-hydroxyphenylglycol-d<em>3</em>
  • HY-17413S
    Zidovudine-d3

    Azidothymidine-d<sub>3sub>; AZT-d<sub>3sub>; ZDV-d<sub>3sub>

    		 Isotope-Labeled Compounds HIV CRISPR/Cas9 Infection
    Zidovudine-d3 is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Zidovudine-d<em>3</em>
  • HY-B1773AS5
    Sodium Propionate-d3

    Mycoban-d<sub>3sub>; Napropion-d<sub>3sub>; Ocuseptine-d<sub>3sub>

    		 Isotope-Labeled Compounds Others
    Sodium Propionate-d3 is the deuterium labeled Sodium Propionate[1].
    Sodium Propionate-d<em>3</em>
  • HY-B0113S
    Omeprazole-d<sub>3sub>

    H 16868-d<sub>3sub>

    		 Proton Pump Bacterial Autophagy Infection Metabolic Disease Cancer
    Omeprazole-d3 is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
    Omeprazole-d<<em>sub>3</em></<em>sub</em>>
  • HY-B0457AS
    Clomipramine-d3

    Chlorimipramine-d<sub>3sub>; G-34586-d<sub>3sub>; NSC-169865-d<sub>3sub>

    		 Serotonin Transporter Dopamine Receptor Neurological Disease
    Clomipramine-d3 is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
    Clomipramine-d<em>3</em>
  • HY-66005S1
    Acetaminophen-d3

    Paracetamol-d<sub>3sub>; 4-Acetamidophenol-d<sub>3sub>; 4'-Hydroxyacetanilide-d<sub>3sub>

    		 COX Histone Acetyltransferase Endogenous Metabolite Inflammation/Immunology
    Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
    Acetaminophen-d<em>3</em>
  • HY-B0141AS
    Alpha-Estradiol-d3

    Alfatradiol-d<sub>3sub>; Epiestradiol-d<sub>3sub>; Epiestrol-d<sub>3sub>

    		 5 alpha Reductase Endogenous Metabolite Inflammation/Immunology
    Alpha-Estradiol-d3 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
    Alpha-Estradiol-d<em>3</em>
  • HY-N0176S
    Dihydroartemisinin-d3

    Dihydroqinghaosu-d<sub>3sub>; β-Dihydroartemisinin-d<sub>3sub>; artenimol-d<sub>3sub>

    		 Parasite NF-κB Autophagy Apoptosis Infection Cancer
    Dihydroartemisinin-d3 is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.
    Dihydroartemisinin-d<em>3</em>
  • HY-30151S
    Methoxsalen-d3

    8-Methoxypsoralen-d<sub>3sub>; Xanthotoxin-d<sub>3sub>; 8-MOP-d<sub>3sub>

    		 Cytochrome P450
    Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].
    Methoxsalen-d<em>3</em>
  • HY-125833
    Alpha-Naphthoflavone
    5 Publications Verification

    		 Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis Cancer
    Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis [3] .
    Alpha-Naphthoflavone
  • HY-A0070AS3
    Liothyronine-d3

    Triiodothyronine-d<sub>3sub>; 3,3',5-Triiodo-L-thyronine-d<sub>3sub>; T3-d<sub>3sub>

    		 Endogenous Metabolite Thyroid Hormone Receptor Isotope-Labeled Compounds Endocrinology Cancer
    Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively [3].
    Liothyronine-d<em>3</em>
  • HY-B0647S1
    Butylphthalide-d3

    3-n-Butylphthalide-d<sub>3sub>; 3-Butylphthalide-d<sub>3sub>

    		 Isotope-Labeled Compounds Neurological Disease
    Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.
    Butylphthalide-d<em>3</em>
  • HY-115127S
    3-Methylanisole-d3

    m-Methoxytoluene-d<sub>3sub>; m-Methylanisole-d<sub>3sub>

    		 Isotope-Labeled Compounds Others
    3-Methylanisole-d3 is the deuterium labeled 3-Methylanisole[1].
    <em>3</em>-Methylanisole-d<em>3</em>
  • HY-B0264S
    Guaifenesin-d3

    Guaiacol glyceryl ether-d<sub>3sub>; Guaiphenesin-d<sub>3sub>; Glycerol guaiacolate-d<sub>3sub>

    		 Isotope-Labeled Compounds Neurological Disease Inflammation/Immunology
    Guaifenesin-d3 is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].
    Guaifenesin-d<em>3</em>
  • HY-15027S
    5-Aminosalicylic Acid-d3 hydrochloride

    Mesalamine-d<sub>3sub> hydrochloride; 5-ASA-d<sub>3sub> hydrochloride; Mesalazine-d<sub>3sub> hydrochloride

    		 Isotope-Labeled Compounds PPAR PAK NF-κB Endogenous Metabolite Inflammation/Immunology Cancer
    5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
    5-Aminosalicylic Acid-d<em>3</em> hydrochloride
  • HY-13636S
    Fulvestrant-d3

    ICI 182780-d<sub>3sub>; ZD 9238-d<sub>3sub>; ZM 182780-d<sub>3sub>

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Autophagy Apoptosis Cancer
    Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].
    Fulvestrant-d<em>3</em>
  • HY-10581AS
    Gatifloxacin-d3 hydrochloride

    AM-1155-d<sub>3sub> hydrochloride; BMS-206584-d<sub>3sub> hydrochloride; PD135432-d<sub>3sub> hydrochloride

    		 Isotope-Labeled Compounds Bacterial Topoisomerase Antibiotic Infection
    Gatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
    Gatifloxacin-d<em>3</em> hydrochloride
  • HY-17509S
    Deracoxib-d3

    SC 046-d<sub>3sub>; SC 46-d<sub>3sub>; SC 59046-d<sub>3sub>

    		 Isotope-Labeled Compounds COX Apoptosis Inflammation/Immunology
    Deracoxib-d3 is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
    Deracoxib-d<em>3</em>
  • HY-15027S1
    5-Aminosalicylic acid-d3

    Mesalamine-d<sub>3sub>; 5-ASA-d<sub>3sub>; Mesalazine-d<sub>3sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite NF-κB PAK PPAR Inflammation/Immunology Cancer
    5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].
    5-Aminosalicylic acid-d<em>3</em>
  • HY-B0579S1
    Cyclosporin A-d3

    Cyclosporine A-d<sub>3sub>; Ciclosporin A-d<sub>3sub>; CsA-d<sub>3sub>

    		 Antibiotic Complement System Molecular Glues Phosphatase Others
    Cyclosporin A-d3 is the d3-labeled Cyclosporin A (HY-B0579)[1].
    Cyclosporin A-d<em>3</em>
  • HY-13757AS1
    Tamoxifen-d3

    ICI 47699-d<sub>3sub>; (Z)-Tamoxifen-d<sub>3sub>; trans-Tamoxifen-d<sub>3sub>

    		 Estrogen Receptor/ERR Apoptosis Autophagy HSP Cancer
    Tamoxifen-d3 is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].
    Tamoxifen-d<em>3</em>
  • HY-B1260S2
    Cetrimonium-d3 bromide

    CTAB-d<sub>3sub>; Cetyltrimethylammonium bromide-d<sub>3sub>; Hexadecyltrimethylammonium-d<sub>3sub> bromide

    		 Isotope-Labeled Compounds Others
    Cetrimonium-d3 (bromide) is the deuterium labeled Cetrimonium bromide[1].
    Cetrimonium-d<em>3</em> bromide
  • HY-B1658S
    Frovatriptan-d3 hydrochloride

    (R)-Frovatriptan-d<sub>3sub> hydrochloride; SB 209509-d<sub>3sub> hydrochloride; VML 251-d<sub>3sub> hydrochloride

    		 5-HT Receptor Neurological Disease
    Frovatriptan-d3 (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].
    Frovatriptan-d<em>3</em> hydrochloride
  • HY-13757S
    Tamoxifen-d3 hydrochloride

    ICI 46474-d<sub>3sub> hydrochloride; (Z)-Tamoxifen-d<sub>3sub> hydrochloride; trans-Tamoxifen-d<sub>3sub> hydrochloride

    		 Apoptosis Estrogen Receptor/ERR Autophagy HSP Isotope-Labeled Compounds Cancer
    Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
    Tamoxifen-d<em>3</em> hydrochloride
  • HY-B0171S
    Antipyrine-d3

    Phenazone-d<sub>3sub>; Phenazon-d<sub>3sub>

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Antipyrine-d3 is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2].
    Antipyrine-d<em>3</em>
  • HY-B0479S
    Thiamphenicol-d3

    Thiophenicol-d<sub>3sub>; Dextrosulphenidol-d<sub>3sub>

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection
    Thiamphenicol-d3 is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
    Thiamphenicol-d<em>3</em>
  • HY-N0136S
    Taxifolin-d3

    (+)-Dihydroquercetin-d<sub>3sub>; (+)-Taxifolin-d<sub>3sub>

    		 Isotope-Labeled Compounds Autophagy Tyrosinase Inflammation/Immunology
    Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
    Taxifolin-d<em>3</em>
  • HY-N0108S
    Physcion-d3

    Parietin-d<sub>3sub>; Rheochrysidin-d<sub>3sub>

    		 Isotope-Labeled Compounds Bacterial Infection Inflammation/Immunology Cancer
    Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects [3].
    Physcion-d<em>3</em>
  • HY-B0215S
    Acetylcysteine-d3

    N-Acetylcysteine-d<sub>3sub>; N-Acetyl-L-cysteine-d<sub>3sub>; NAC-d<sub>3sub>

    		 Isotope-Labeled Compounds Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Infection Neurological Disease
    Acetylcysteine-d3 is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].
    Acetylcysteine-d<em>3</em>
  • HY-15455S2
    Roflumilast-d3

    APTA-2217-d<sub>3sub>; BYK 20869-d<sub>3sub>; B9302-107-d<sub>3sub>

    		 Isotope-Labeled Compounds Phosphodiesterase (PDE) RSV Inflammation/Immunology
    Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
    Roflumilast-d<em>3</em>
  • HY-Y1002S
    Methionol-d3

    3-Hydroxypropyl methyl sulfide-d<sub>3sub>; 3-Methylmercapto-1-propanol-d<sub>3sub>; 4-Thiapentan-1-ol-d<sub>3sub>; gamma-Hydroxypropyl methyl sulfide-d<sub>3sub>

    		 Isotope-Labeled Compounds Others
    Methionol-d3 is deuterated labeled ((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)-L-asparagine.
    Methionol-d<em>3</em>
  • HY-B0495S
    Lamotrigine-13C3,d3

    LTG-13C<sub>3sub>,d<sub>3sub>; BW430C-13C<sub>3sub>,d<sub>3sub>

    		 Sodium Channel Autophagy Neurological Disease
    Lamotrigine- 13C3,d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
    Lamotrigine-13C<em>3</em>,d<em>3</em>
  • HY-75087S
    (R)-Pyrrolidine-2-carboxylic acid-d3

    (+)-(R)-Proline-d<sub>3sub>; (R)-(+)-Proline-d<sub>3sub>; (R)-2-Carboxypyrrolidine-d<sub>3sub>; (R)-Proline-d<sub>3sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    (R)-Pyrrolidine-2-carboxylic acid-d3 is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.
    (R)-Pyrrolidine-2-carboxylic acid-d<em>3</em>
  • HY-N0402S
    Artemether-d3

    Dihydroqinghaosu methyl ether-d<sub>3sub>; Dihydroartemisinin methyl ether-d<sub>3sub>; SM224-d<sub>3sub>

    		 Isotope-Labeled Compounds Parasite Infection Cancer
    Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
    Artemether-d<em>3</em>
  • HY-B0302AS
    Etidronic acid-d3 disodium

    Etidronate-d<sub>3sub> disodium; HEDPA-d<sub>3sub> disodium; HEDP-d<sub>3sub> disodium

    		 Apoptosis Isotope-Labeled Compounds Others
    Etidronic acid-d3 (disodium) is the deuterium labeled Etidronic acid disodium[1].
    Etidronic acid-d<em>3</em> disodium
  • HY-W008794S
    Normetanephrine-d3 hydrochloride

    (±)-Normetanephrine-d<sub>3sub> (hydrochloride); DL-Normetanephrine-d<sub>3sub> (hydrochloride); (Rac)-Normetanephrine-d<sub>3sub> (hydrochloride)

    		 Endogenous Metabolite Metabolic Disease
    Normetanephrine-d3 (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE)[1].
    Normetanephrine-d<em>3</em> hydrochloride
  • HY-107854S
    N-Acetyl-5-hydroxytryptamine-d3

    N-Acetylserotonin-d<sub>3sub>; Normelatonin-d<sub>3sub>; O-Demethylmelatonin-d<sub>3sub>

    		 Endogenous Metabolite Trk Receptor Neurological Disease
    N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].
    N-Acetyl-5-hydroxytryptamine-d<em>3</em>
  • HY-B0457S
    Clomipramine-d3 hydrochloride

    Chlorimipramine-d<sub>3sub> (hydrochloride); G-34586-d<sub>3sub> (hydrochloride); NSC-169865-d<sub>3sub> (hydrochloride)

    		 Serotonin Transporter Dopamine Receptor Neurological Disease
    Clomipramine-d3 (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
    Clomipramine-d<em>3</em> hydrochloride
  • HY-13318S
    Oseltamivir acid-d3

    GS 4071-d<sub>3sub>; Ro 64-0802-d<sub>3sub>; Oseltamivir carboxylate-d<sub>3sub>

    		 Influenza Virus Infection
    Oseltamivir acid-d3 is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses[1][2].
    Oseltamivir acid-d<em>3</em>
  • HY-B0617S
    S-Adenosyl-L-methionine-d3

    S-Adenosyl methionine-d<sub>3sub>; Ademetionine-d<sub>3sub>; AdoMet-d<sub>3sub>

    		 Endogenous Metabolite Neurological Disease Inflammation/Immunology Cancer
    S-Adenosyl-L-methionine-d3 is the deuterated product of S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is endogenously produced from methionine and ATP through the action of methionine adenosyltransferase and is an important orally active methyl donor .
    S-Adenosyl-L-methionine-d<em>3</em>
  • HY-41700S
    D-Alanine-d3

    (R)-Alanine-d<sub>3sub>; Ba 2776-d<sub>3sub>; D-α-Alanine-d<sub>3sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    D-Alanine-d3 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
    D-Alanine-d<em>3</em>
  • HY-101064S2
    Fmoc-leucine-d3

    N-FMOC-leucine-d<sub>3sub>; NPC 15199-d<sub>3sub>; NSC 334290-d<sub>3sub>

    		 PPAR
    Fmoc-leucine-d3 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
    Fmoc-leucine-d<em>3</em>
  • HY-14654S
    Aspirin-d3

    Acetylsalicylic Acid-d<sub>3sub>; ASA-d<sub>3sub>

    		 COX Autophagy Mitophagy Virus Protease Inflammation/Immunology Cancer
    Aspirin-d3 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.
    Aspirin-d<em>3</em>
  • HY-B1037S
    Salbutamol-d3

    Albuterol-d<sub>3sub>; AH-3365-d<sub>3sub>

    		 Adrenergic Receptor Neurological Disease Endocrinology
    Salbutamol-d3 is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).
    Salbutamol-d<em>3</em>
  • HY-B0272S
    Rifampicin-d3

    Rifampin-d<sub>3sub>; Rifamycin AMP-d<sub>3sub>

    		 Bacterial Influenza Virus Antibiotic Infection
    Rifampicin-d3 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities[1][2].
    Rifampicin-d<em>3</em>

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